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WWC1 Antibody

CAT: 0223-7991-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7991-01Size:0.02 mg
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Background
The WW and C2 domain containing 1 (WWC1) protein, also known as KIBRA, possesses two WW domains and an internal C2-like domain (1) . WWC1 was originally identified as a memory performance-associated protein in humans (2) and has recently been shown to be a novel regulator of the Hippo pathway (3) . WWC1 is phosphorylated by the mitotic kinases Aurora-A and –B (4), and in turn activates the Aurora kinases and is required for precise chromosome alignment during mitosis (5) .
NCBI Gene ID
23286
Swiss Prot
Q8IX03
Accession Number
NP_001155133
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Neuroscience
Purification
WWC1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
WWC1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
WWC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
WWC1 antibody is human, mouse and rat reactive. At least three isoforms of WWC1 are known to exist; this antibody will detect all three isoforms.
Symbol
WWC1
NCBI Official Name
WW and C2 domain containing 1
NCBI Organism
Homo sapiens
Background Reference 01
Kremerskothen J, Plaas C, Buther K, et al. Characterization of KIBRA, a novel WW domain-containing protein. Biochem. Biophys. Res. Commun. 2003; 300:862-7.
Background Reference 02
Papassotiropoulos A, Stephan DA, Huentelman MJ, et al. Common Kibra alleles are associated with human memory performance. Science 2006; 314:475-8.
Background Reference 03
Genevet A, Wehr MC, Brain R, et al. Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev. Cell 2010; 18:309-16.
Background Reference 04
Xiao L, Chen Y, Ji M, et al. KIBRA protein phosphorylation is regulated by mitotic kinase aurora and protein phosphatase 1. J. Biol. Chem. 2011; 286:36304-15.
Other Product Names
WW and C2 domain containing 1, HBEBP3, HBEBP36, KIBRA, MEMRYQTL
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
242247251
Physical Properties
Liquid

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