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GPRASP1 Antibody

CAT: 0223-7987-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7987-01Size:0.02 mg
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Background
The G protein-coupled receptor associated sorting protein 1 (GPRASP1) is a member of the GPRASP family and is thought to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors (1,2) . GPRASP1 interacts with receptors such as the D2 dopamine receptor (DRD2), delta opioid receptor (OPRD1), beta-2 adrenergic receptor (ADRB2), D4 dopamine receptor (DRD4) and cannabinoid 1 receptor (CNR1) and targets these proteins for degradation in lysosomes (2) . Recently, it has been shown that increased GPRASP1 levels may act as a potential biomarker for breast cancer (3) .
NCBI Gene ID
9737
Swiss Prot
Q5JY77
Accession Number
NP_001171656
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
GPRASP1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
GPRASP1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
GPRASP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
GPRASP1 antibody is human and mouse reactive. This antibody is predicted to not cross-react with GPRASP2.
Symbol
GPRASP1
NCBI Official Name
G protein-coupled receptor associated sorting protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Simonin F, Karcher P, Boeuf JJ, et al. Identification of a novel family of G protein-coupled receptor associated proteins. J. Neurochem. 2004; 89:766-75.
Background Reference 02
Moser E, Kargl J, Whistler JL, et al. G protein-coupled receptor-associated sorting protein 1 regulates the postendocytic sorting of seven-transmembrane-spanning G protein-coupled receptors. Pharmacology 2010; 86:22-9.
Background Reference 03
Tuszynski GP, Rothman VL, Zheng X, et al. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer. Exp. Mol. Pathol. 2011; 91:608-13.
Other Product Names
G-protein coupled receptor-associated sorting protein 1, GASP, GASP-1, GASP1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
296080706
Physical Properties
Liquid

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