KIRREL3 Antibody

• Background:

  KIRREL3, also known as nephrin-like protein 2, is a type I transmembrane protein belonging to a family of three podocin interacting proteins and the immunoglobulin superfamily (1) . KIRREL3 is involved in the regulation of both glomerular and neural development (2), and more specifically, the nucleogenesis of the pontine nuclei in the developing hindbrain (3) . KIRREL3 has also been shown to interact with the synaptic scaffold protein calmodulin-associated serine/threonine kinase (CASK) in neuronal cells (4) .

• NCBI Gene ID:

  84623

• Swiss Prot:

  Q8IZU9

• Accession Number:

  NP_115920

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Stem Cell

• Purification:

  KIRREL3 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1405 - Mouse Kidney Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  KIRREL3 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  KIRREL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  KIRREL3 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. KIRREL3 antibody is predicted to not cross-react with other members of the KIRREL protein family.

• Symbol:

  KIRREL3

• NCBI Official Name:

  Kin of IRRE like 3 (Drosophila)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sellin L, Huber TB, Gerke P, et al. NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 2003; 17:115-7.

• Background Reference 02:

  Neumann-Haefelin E, Kramer-Zucker A, Slanchev K, et al. A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Hum. Mol. Genet. 2010; 19:2347-59.

• Background Reference 03:

  Nishida K, Nakayama K, Yoshimura S, et al. Role of Neph2 in pontine nuclei formation in the developing hindbrain. Mol. Cell Neurosci. 2011; 46:662-70.

• Background Reference 04:

  Mizuhara E, Minaki Y, Nakatani T, et al. Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin. Dev. Biol. 2010; 338:202-14.

• Other Product Names:

  Kin of irregular chiasm-like protein 3, Kin of IRRE-like protein 3, MRD4, KIRRE, NEPH2, PRO4502, Nephrin-like protein 2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  26006461

• Physical Properties:

  Liquid