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NLGN2 Antibody

CAT: 0223-7969-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7969-01Size:0.02 mg
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Background
Neuroligin 2 (NLGN2) is a member of a family of neuronal cell surface proteins that localize to the post-synaptic membrane (1,2) . Neuroligins are thought to act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses (2) . NLGN2 has been shown to control perisomatic inhibitory synapse maturation together with gephyrin and collybistin, thereby regulating GABA receptor clustering on neurons (3,4) . NLGN2 also exhibits differential functions at different types of inhibitory synapses on the same postsynaptic neuron (5) .
NCBI Gene ID
57555
Swiss Prot
Q8NFZ4
Accession Number
NP_065846
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
NLGN2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
NLGN2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
NLGN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
NLGN2 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. NLGN2 antibody is predicted to not cross-react with other members of the NLGN protein family.
Symbol
NLGN2
NCBI Official Name
Neuroligin 2
NCBI Organism
Homo sapiens
Background Reference 01
Ichtchenko K, Nguyen T, and Sudhof TC. Structures, alternative splicing, and neurexin binding of multiple neuroligins. J. Biol. Chem. 1996; 271:2676-82.
Background Reference 02
Bang ML and Owczarek S. A matter of balance: role of neurexin and neuroligin at the synapse. Neurochem. Res. 2013; 38:1174-89.
Background Reference 03
Poulopoulos A, Aramuni G, Meyer G, et al. Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitiory synapses through gephyrin and collybistin. Neuron 2009; 63:628-42.
Background Reference 04
Jedlicka P, Hoon M, Poulopoulos T, et al. Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo. Cereb. Cortex 2011; 21:357-67.
Other Product Names
Neuroligin 2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
30840978
Physical Properties
Liquid

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