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XKR8 Antibody

CAT: 0223-7965-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7965-01Size:0.02 mg
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Background
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1) . XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2) .
NCBI Gene ID
55113
Swiss Prot
Q9H6D3
Accession Number
NP_060523
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis
Purification
XKR8 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1319 - Human Stomach Tissue Lysate
Concentration
1 mg/mL
Buffer
XKR8 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
XKR8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
Symbol
XKR8
Positive Control 2
Cat. No. 10-801 - Human Stomach Tissue Slide
NCBI Official Name
XK, Kell blood group complex subunit-related family, member 8
NCBI Organism
Homo sapiens
Background Reference 01
Suzuki J, Denning DP, Imanishi E, et al. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013; 341:403-6.
Background Reference 02
Wang X, Wu YC, Fadok VA, et al. Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science 2003; 302:1563-6.
Other Product Names
XKR8 Antibody: XRG8, hXkr8, XRG8, XK-related protein 8
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
24431977
Physical Properties
Liquid

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