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UVRAG Antibody

CAT: 0223-7947-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7947-01Size:0.02 mg
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Background
The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1) . UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2) . UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3) . UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5) .
NCBI Gene ID
7405
Swiss Prot
Q9P2Y5
Accession Number
NP_003360
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
UVRAG antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1402 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
UVRAG antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
UVRAG antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
UVRAG antibody is human and mouse reactive.
Symbol
UVRAG
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
UV radiation resistance associated
NCBI Organism
Homo sapiens
Background Reference 01
Stack JH, DeWald DB, Takegawa K, et al. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 1995; 129:321-34.
Background Reference 02
Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006; 8:688-99.
Background Reference 03
Liang C, Lee JS, Inn KS, et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 2008; 10:776-87.
Background Reference 04
Ionov Y, Nowak N, Perucho M, et al. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. Oncogene 2004; 23:639-45.
Other Product Names
UVRAG Antibody: p63, DHTX, VPS38, UV radiation resistance-associated gene protein, p63
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
21687212
Physical Properties
Liquid

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