UVRAG Antibody

• Background:

  The class III type phosphoinositide 3-kinase (PI3KC3) / Vps34 regulates vacuolar trafficking as well as autophagy (1) . UVRAG (UV radiation resistance-associated gene) is associated with the Beclin-1/PI3KC3 complex and promotes PI3KC3 enzymatic activity and autophagy, while suppressing proliferation (2) . UVRAG is highly expressed in brain, lung, kidney and liver and contains one C2 domain, which is involved in calcium-dependent phospholipid binding. Beclin-1 binding to UVRAG promotes both autophagosome maturation and endocytic trafficking (3) . UVRAG is also a potential tumor suppressor protein with frameshift mutations observed in colon and gastric carcinomas (4,5) .

• NCBI Gene ID:

  7405

• Swiss Prot:

  Q9P2Y5

• Accession Number:

  NP_003360

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy

• Purification:

  UVRAG antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1402 - Mouse Lung Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  UVRAG antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  UVRAG antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  UVRAG antibody is human and mouse reactive.

• Symbol:

  UVRAG

• Positive Control 2:

  Cat. No. 10-101 - Human Lung Tissue Slide

• NCBI Official Name:

  UV radiation resistance associated

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Stack JH, DeWald DB, Takegawa K, et al. Vesicle-mediated protein transport: regulatory interactions between the Vps15 protein kinase and the Vps34 PtdIns 3-kinase essential for protein sorting to the vacuole in yeast. J. Cell Biol. 1995; 129:321-34.

• Background Reference 02:

  Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 2006; 8:688-99.

• Background Reference 03:

  Liang C, Lee JS, Inn KS, et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 2008; 10:776-87.

• Background Reference 04:

  Ionov Y, Nowak N, Perucho M, et al. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. Oncogene 2004; 23:639-45.

• Other Product Names:

  UVRAG Antibody: p63, DHTX, VPS38, UV radiation resistance-associated gene protein, p63

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  21687212

• Physical Properties:

  Liquid