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BAMBI Antibody

CAT: 0223-7931-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7931-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development (1) . BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4 (2,3) . BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues (4) . BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines (5) .
NCBI Gene ID
25805
Swiss Prot
Q13145
Accession Number
NP_036474
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Stem Cell
Purification
BAMBI antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1402 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Sheep: (88%)
Buffer
BAMBI antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BAMBI antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
BAMBI antibody is human, mouse and rat reactive.
Symbol
BAMBI
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
BMP and activin membrane-bound inhibitor
NCBI Organism
Homo sapiens
Background Reference 01
Onichtchouk D, Chen YG, Dosch R, et al. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature 1999; 401:480-5.
Background Reference 02
Yan X, Lin Z, Chen F, et al. Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling. J Biol. Chem. 2009; 284:30097-104.
Background Reference 03
Grotewold L, Plum M, Dildrop R, et al. Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech. Dev. 2001; 100:327-30.
Background Reference 04
Fritzmann J, Morkel M, Besser D, et al. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 2009; 137:165-75.
Other Product Names
BMP and activin membrane-bound inhibitor homolog
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
6912534
Physical Properties
Liquid

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