HDAC2 Antibody

CAT: 0223-7899-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7899-01Size:0.02 mg
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Background
The histone deacetylase (HDAC) family contains multiple members which are divided into four classes. Class I of the HDAC family comprises four members, HDAC1, 2, 3, and 8, each of which contains a deacetylase domain and exhibits a different, individual substrate specificity and function in vivo (1) . HDAC2 was first identified as as a mammalian homolog to the yeast transcriptional regulator RPD3 (2) . HDAC2 forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor (2,3) . Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events (4) .
NCBI Gene ID
3066
Swiss Prot
Q92769
Accession Number
NP_001518
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Stem Cell
Purification
HDAC2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (94%)
Buffer
HDAC2 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
HDAC2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
HDAC2 antibody is human, mouse and rat reactive. At least two isoforms of HDAC2 are known to exist; this antibody will detect both isoforms. HDAC2 antibody is predicted to not cross-react with other members of the HDAC family.
Symbol
HDAC2
NCBI Official Name
Histone deacetylase 2
NCBI Organism
Homo sapiens
Background Reference 01
Taunton J, Hassig CA, and Schreiber SL. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 1996; 272:408-11.
Background Reference 02
Yang WM, Inouye C, Zeng Y, et al. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. USA 1996; 93:12845-50.
Background Reference 03
Cress WD and Seto E. Histone deacetylases, transcriptional control, and cancer. J. Cell Phys. 2000; 184:1-16.
Background Reference 04
Kramer OH. HDAC2: a critical factor in health and disease. Trends Pharmacol. Sci. 2009; 30:647-55.
Other Product Names
HDAC2 Antibody: HD2, RPD3, YAF1, Histone deacetylase 2, HD2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
293336691
Physical Properties
Liquid

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