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ANGPTL3 Antibody

CAT: 0223-7865-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7865-01Size:0.02 mg
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Background
The angiopoietin-related protein 3 (ANGPTL3) is a member of a family of secreted proteins that function in angiogenesis (1) . ANGPTL3 is processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis (2,3) . Recent experiments have shown that a deficiency of ANGPTL3 is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids, suggesting that ANGPTL3 may also play a role in modulating glucose metabolism (4) .
NCBI Gene ID
27329
Swiss Prot
Q9Y5C1
Accession Number
NP_055310
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Obesity
Purification
ANGPTL3 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Buffer
ANGPTL3 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ANGPTL3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
ANGPTL3 antibody is human, mouse and rat reactive. ANGPTL3 antibody is predicted not to cross-react with other ANGPTL family proteins.
Symbol
ANGPTL3
NCBI Official Name
Angiopoietin-like 3
NCBI Organism
Homo sapiens
Background Reference 01
Conklin D, Gilbertson D, Taft DW, et al. Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics 1999; 62:477-82.
Background Reference 02
Koishi R, Ando Y, Ono M, et al. Angptl3 regulates lipid metabolism in mice. Nat. Genet. 2002; 30:151-7.
Background Reference 03
Camenisch G, Pisabarro MT, Sherman D, et al. ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.J. Biol. Chem. 2002; 277:17281-90.
Background Reference 04
Robciuc MR, Maranghi M, Lahikainen A, et al. Angptl3 deficiency is associated with increased insulin sensitivity, lipoprotein lipase activity, and decreased serum free fatty acids. Arterioscler. Thromb. Vasc. Biol. 2013; 33:1706-13.
Other Product Names
ANGPTL3 Antibody: ANL3, ANG-5, FHBL2, ANGPT5, UNQ153/PRO179, Angiopoietin-related protein 3, Angiopoietin-5
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7656888
Physical Properties
Liquid

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