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MFN1 Antibody

CAT: 0223-7861-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7861-01Size:0.02 mg
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Background
Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1,2) . MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3) . When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4) .
NCBI Gene ID
55669
Swiss Prot
Q8IWA4
Accession Number
NP_284941
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Apoptosis
Purification
MFN1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Buffer
MFN1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MFN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
MFN1 antibody is human, mouse and rat reactive. MFN1 antibody is predicted to not cross-react with MFN2.
Symbol
MFN1
Positive Control 2
Cat. No. 17-002 - A-431 Cell Slide
NCBI Official Name
Mitofusin 1
NCBI Organism
Homo sapiens
Background Reference 01
Chen H, Detmer SA, Ewald AJ, et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 2003; 160:189-200.
Background Reference 02
Ishihara N, Eura Y, and Mihara K. Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity. J. Cell Sci. 2004; 117:6535-46.
Background Reference 03
Chen H, Detmer SA, Ewald AJ, et al. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J. Cell Biol. 2003; 160:189-200.
Background Reference 04
Ryu SW, Choi K, Park JH, et al. Mitofusin 1 inhibits an apoptosis-associated amino-terminal conformational change in Bax, but not its mitochondrial translocation, in a GTPase-dependent manner. Cancer Lett. 2012; 323:62-8.
Other Product Names
MFN1 Antibody: hfzo1, hfzo2, Mitofusin-1, Fzo homolog
Tested Applications
ELISA, WB, ICC
Protein ID
45269137
Physical Properties
Liquid

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