PINK1 Antibody

• Background:

  The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1) . PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2) . PINK1 is cleaved by the mitochondrial protease PARL (3) . Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4) .

• NCBI Gene ID:

  65018

• Swiss Prot:

  Q9BXM7

• Accession Number:

  NP_115785

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy, Neuroscience

• Purification:

  PINK1 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1202 - A431 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  PINK1 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  PINK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  PINK1 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1.

• Symbol:

  PINK1

• Positive Control 2:

  Cat. No. 1406 - Mouse Spleen Tissue Lysate

• Positive Control 3:

  Cat. No. 1466 - Rat Spleen Tissue Lysate

• NCBI Official Name:

  PTEN induced putative kinase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Matsuda S, Kitagishi Y, and Kobayashi M. Function and characteristics of PINK1 in mitochondria. Oxid. Med. Cell. Longev. 2013;601587.

• Background Reference 02:

  Corti O, Lesage S, and Brice A. What genetics tells us about the causes and mechanism of Parkinson's disease. Physiol. Rev. 2011; 91:1161-218.

• Background Reference 03:

  Deas E, Plun-Favreau H, and Gandhi S, et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum. Mol. Genet. 2011; 20:867-79.

• Background Reference 04:

  Valente EM, Abou-Sleiman PM, Caputo V, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 304:1158-60.

• Other Product Names:

  PINK1 Antibody: BRPK, PARK6BRPK

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  14165272

• Physical Properties:

  Liquid