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PINK1 Antibody

CAT: 0223-7859-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7859-01Size:0.02 mg
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Background
The PTEN-induced putative kinase 1 (PINK1) is a serine/threonine protein kinase that localizes to mitochondria and is thought to protect cells from stress-induced mitochondrial dysfunction (reviewed in 1) . PINK1 recruits the E3 ubiquitin ligase Parkin to mitochondria to initiate mitophagy, an autophagic process that clears damaged mitochondria within a cell (2) . PINK1 is cleaved by the mitochondrial protease PARL (3) . Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease (4) .
NCBI Gene ID
65018
Swiss Prot
Q9BXM7
Accession Number
NP_115785
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy, Neuroscience
Purification
PINK1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1202 - A431 Cell Lysate
Concentration
1 mg/mL
Buffer
PINK1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PINK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
PINK1 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will only detect the longer isoform. PINK1 antibody will detect the cleaved and uncleaved form of PINK1.
Symbol
PINK1
Positive Control 2
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Positive Control 3
Cat. No. 1466 - Rat Spleen Tissue Lysate
NCBI Official Name
PTEN induced putative kinase 1
NCBI Organism
Homo sapiens
Background Reference 01
Matsuda S, Kitagishi Y, and Kobayashi M. Function and characteristics of PINK1 in mitochondria. Oxid. Med. Cell. Longev. 2013;601587.
Background Reference 02
Corti O, Lesage S, and Brice A. What genetics tells us about the causes and mechanism of Parkinson's disease. Physiol. Rev. 2011; 91:1161-218.
Background Reference 03
Deas E, Plun-Favreau H, and Gandhi S, et al. PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum. Mol. Genet. 2011; 20:867-79.
Background Reference 04
Valente EM, Abou-Sleiman PM, Caputo V, et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004; 304:1158-60.
Other Product Names
PINK1 Antibody: BRPK, PARK6BRPK
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
14165272
Physical Properties
Liquid

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