DOCK8 Antibody

• Background:

  The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors (1) . DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse (reviewed in 2) . Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome (3) .

• NCBI Gene ID:

  81704

• Swiss Prot:

  Q8NF50

• Accession Number:

  NP_982272

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology

• Purification:

  DOCK8 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1287 - EL4 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  DOCK8 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  DOCK8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  DOCK8 antibody is human, mouse and rat reactive. Multiple isoforms of DOCK8 are known to exist.

• Symbol:

  DOCK8

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  Dedicator of cytokinesis 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ruusala A and Aspenstrom P. Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology. FEBS Lett. 2004; 572:159-66.

• Background Reference 02:

  Randall KL, Lambe T, Goodnow CC, et al. The essential role of DOCK8 in humoral immunity. Dis. Markers 2010; 29:141-50.

• Background Reference 03:

  Engelhardt KR, McGhee S, Sinkler S, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal recessive form of hyper-IgE syndrome. J. Allergy Clin. Immunol. 2009; 124:1289-302.

• Other Product Names:

  DOCK8 Antibody: MRD2, ZIR8, HEL-205, Dedicator of cytokinesis protein 8

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  238231392

• Physical Properties:

  Liquid