DOCK8 Antibody

CAT: 0223-7847-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7847-01Size:0.02 mg
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Background
The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors (1) . DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse (reviewed in 2) . Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome (3) .
NCBI Gene ID
81704
Swiss Prot
Q8NF50
Accession Number
NP_982272
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
DOCK8 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1287 - EL4 Cell Lysate
Concentration
1 mg/mL
Buffer
DOCK8 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DOCK8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
DOCK8 antibody is human, mouse and rat reactive. Multiple isoforms of DOCK8 are known to exist.
Symbol
DOCK8
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
Dedicator of cytokinesis 8
NCBI Organism
Homo sapiens
Background Reference 01
Ruusala A and Aspenstrom P. Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology. FEBS Lett. 2004; 572:159-66.
Background Reference 02
Randall KL, Lambe T, Goodnow CC, et al. The essential role of DOCK8 in humoral immunity. Dis. Markers 2010; 29:141-50.
Background Reference 03
Engelhardt KR, McGhee S, Sinkler S, et al. Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal recessive form of hyper-IgE syndrome. J. Allergy Clin. Immunol. 2009; 124:1289-302.
Other Product Names
DOCK8 Antibody: MRD2, ZIR8, HEL-205, Dedicator of cytokinesis protein 8
Tested Applications
ELISA, WB, IHC-P
Protein ID
238231392
Physical Properties
Liquid

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