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WAPL Antibody

CAT: 0223-7799-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7799-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
WAPL (wings apart-like), also known as WAPAL or FOE, is a 1,190 amino acid protein that contains one WAPL domain and may play an important role in cell growth (1) . It is expressed in an isoform dependent manner in heart, skeletal muscle (isoform 2) and uterine cervix tumor tissue (isoform 1) (1,2,4) . WAPL is involved in sister-chromatid adhesion and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits (3,4) . WAPL is a new regulator of the development and metastasis of cancerous tissue (4,5) .
NCBI Gene ID
23063
Swiss Prot
Q7Z5K2
Accession Number
NP_055860
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Stem Cell
Purification
WAPL antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1288 - A20 Cell Lysate
Concentration
1 mg/mL
Buffer
WAPL antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
WAPL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
WAPL antibody is human, mouse and rat reactive. At least four isoforms of WAPL are known to exist.
Symbol
WAPAL
NCBI Official Name
Wings apart-like homolog (Drosophila)
NCBI Organism
Homo sapiens
Background Reference 01
Kwiatkowski BA, Ragoczy T, Ehly J, et al. Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2. Exp. Cell Res. 2004; 300:223-33.
Background Reference 02
Kueng S, Hegemann B, Peters BH, et al. Wapl controls the dynamic association of cohesion with chromatin. Cell 2006; 127:955-67.
Background Reference 03
Gandhi R, Gillespie PJ, and Hirano T. Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr. Biol. 2006; 16:2406-17.
Background Reference 04
Oikawa K, Ohbayashi T, Kiyono T, et al. Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression. Cancer Res. 2004; 64:3545-9.
Other Product Names
WAPL Antibody: FOE, WAPL, KIAA0261, FOE, Wings apart-like protein homolog, Friend of EBNA2 protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
42734325
Physical Properties
Liquid

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