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CRH Antibody

CAT: 0223-7797-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7797-01Size:0.02 mg
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Background
Corticotropin-releasing hormone (CRH) is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress (1) . In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta where it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturitio (2) . Marked reduction in this protein has been observed in association with Alzheimer disease (3) .
NCBI Gene ID
1392
Swiss Prot
P06850
Accession Number
NP_000747
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis, Neuroscience
Purification
CRH antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1309 - Human Placenta Tissue Lysate
Concentration
1 mg/mL
Buffer
CRH antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CRH antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
CRH antibody is human specific.
Symbol
CRH
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Corticotropin releasing hormone
NCBI Organism
Homo sapiens
Background Reference 01
Maras PM and Baram TZ. Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012; 315-24.
Background Reference 02
Vrachnis N, Malamas FM, Sifakis S, et al. Immune aspects and myometrial actions of progesterone and CRH in labor. Clin. Dev. Immunol. 2012; 937618.
Background Reference 03
Leake A, Perry EK, Perry RH, et al. Neocortical concentrations of neuropeptides in senile dementia of the Alzheimer and Lewy body type: comparison with Parkinson's disease and severity correlations. Biol. Psychiatry 1991; 29:357-64.
Other Product Names
CRH Antibody: CRF, Corticoliberin, Corticotropin-releasing factor, CRF
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4503041
Physical Properties
Liquid

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