FKBP12 Antibody

• Background:

  FKBP, or FK506 binding protein, is a family of proteins that have prolyl isomerase activity and are related to the cyclophilins in function (1) . FKBP12, also called FKBP1, was originally identified as a target of FK506 and rapamycin activity and catalyzes the transition between cis and transproline residues critical for proper folding of proteins (2) . FKBP12 is an abundant, evolutionarily conserved cytoplasmic protein that is an important regulator of diverse array of cellular processes including T cell activation, entry into the cell cycle and intracellular calcium release (3-5) .

• NCBI Gene ID:

  2280

• Swiss Prot:

  P62942

• Accession Number:

  NP_463460

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis, Immunology

• Purification:

  FKBP12 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1202 - A431 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rabbit: (100%)

• Buffer:

  FKBP12 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  FKBP12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  FKBP12 antibody is human, mouse and rat reactive.

• Symbol:

  FKBP1A

• Positive Control 2:

  Cat. No. 17-002 - A-431 Cell Slide

• NCBI Official Name:

  FK506 binding protein 1A, 12kDa

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Siekierka JJ, Hung SH, Poe M, et al. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature 1989; 341:755-7.

• Background Reference 02:

  Michnick SW, Rosen MK, Wandless TJ, et al. Solution structure of FKBP, a rotamase enzyme and receptor for FK506 and rapamycin. Science 1991; 252:836-9.

• Background Reference 03:

  Wang T, Donahoe PK, and Zervos AS. Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science 1994; 265:674-6.

• Background Reference 04:

  Wen H, Kang S, Song Y, et al. Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels. Arch. Biochem. Biophys. 2012; 517:37-42.

• Other Product Names:

  FKBP12 Antibody: FKBP1, PKC12, PKCI2, FKBP12, PPIASE, FKBP-12, FKBP-1A, FKBP1, Peptidyl-prolyl cis-trans isomerase FKBP1A, 12 kDa FK506-binding protein, PPIase FKBP1A

• Tested Applications:

  ELISA, WB, ICC, IF

• Protein ID:

  17149836

• Physical Properties:

  Liquid