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OASL Antibody

CAT: 0223-7775-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7775-01Size:0.02 mg
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Background
OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1) . It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3) . Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4) .
NCBI Gene ID
8638
Swiss Prot
Q15646
Accession Number
NP_003724
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
OASL antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1410 - Mouse Bladder Tissue Lysate
Concentration
1 mg/mL
Buffer
OASL Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
OASL antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
OASL antibody is human, mouse and rat reactive.
Symbol
OASL
Positive Control 2
Cat. No. 17-011 - Hep G2 Cell Slide
NCBI Official Name
2'-5'-oligoadenylate synthetase-like
NCBI Organism
Homo sapiens
Background Reference 01
Rebouillat D, Marie I, and Hovanessian AG. Molecular cloning and characterization of two related and interferon-induced 56 kDa and 30 kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Eur. J. Biochem. 1998; 257:319-30.
Background Reference 02
Hartmann R, Olsen HS, Widder S, et al. p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family. Nucleic Acids Res. 1998; 26:4121-8.
Background Reference 03
Hovnanian A, Rebouillat D, Levy ER, et al. The human 2',5'-oligoadenylate synthetaselike gene (OASL) encoding the interferon-induced 56 kDa protein maps to chromosome 12q24.2 in the proximity of the 2',5'-OAS locus. Genomics 1999; 56:362-3.
Background Reference 04
Andersen JB, Strandbygård DJ, Hartmann R, et al. Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1. Eur. J. Biochem. 2004; 271:628-36.
Other Product Names
OASL Antibody: OASLd, TRIP14, TRIP-14, p59OASL, p59 OASL, p59-OASL, Thyroid receptor-interacting protein 14, TR-interacting protein 14
Tested Applications
ELISA, WB, ICC, IF
Protein ID
11321577
Physical Properties
Liquid

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