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DCNP1 Antibody

CAT: 0223-7769-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7769-01Size:0.02 mg
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Background
The DCNP1 (dendritic cell nuclear protein 1) gene is specifically expressed in dendritic cells, potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response (1) . It is localized mainly in the perinucleus. One of the alleles (A/T) of this gene causes premature translation termination at aa 117 and has been associated with an increased prevalence of major depression in humans (2,3) . DCNP1 may play a role in the pathogenesis of depressive disorders by enhancing corticotropin-releasing hormone expression in the hypothalamic paraventricular nucleus (4) .
NCBI Gene ID
140947
Swiss Prot
Q8TF63
Accession Number
NP_570900
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
DCNP1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1407 - Mouse Skeletal Muscle Tissue Lysate
Concentration
1 mg/mL
Buffer
DCNP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DCNP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
DCNP1 antibody is human, mouse and rat reactive.
Symbol
C5orf20
NCBI Official Name
Chromosome 5 open reading frame 20
NCBI Organism
Homo sapiens
Background Reference 01
Masuda M, Senju S, Fujii Si S, et al. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. Biochem. Biophys. Res. Commun. 2002; 290:1022-9.
Background Reference 02
Willis-Owen SA, Shifman S, Copley RR, et al. DCNP1: a novel candidate gene for major depression. Mol. Psychiatry 2006; 11:121-2.
Background Reference 03
Bosker FJ, Hartman CA, Nolte IM, et al. Poor replication of candidate genes for major depressive disorder using genome-wide association data. Mol. Psychiatry 2011; 16:516-32.
Background Reference 04
Zhou T, Wang S, Ren H, et al. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. Brain 2010; 133:3069-79.
Other Product Names
DCNP1 Antibody: DCNP1, C5orf20, Dendritic cell nuclear protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
18677770
Physical Properties
Liquid

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