UBIAD1 Antibody

• Background:

  The UbiA prenyltransferase domain containing 1 (UBIAD1) protein , also known as TERE1, was initially identified as a down-regulated gene in transitional cell carcinoma of the bladder (1) . Recently it has been shown to bind the cholesterol carrier APOE and modulate cellular cholesterol levels (2) . Mutations in the UBIAD1 gene can cause Schnyder crystalline corneal dystrophy, an autosomal dominant disease characterized by progressive opacification of the cornea resulting from the local accumulation of lipids (3) .

• NCBI Gene ID:

  29914

• Swiss Prot:

  Q9Y5Z9

• Accession Number:

  NP_037451

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  UBIAD1 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1404 - Mouse Liver Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Chicken: (87%)

• Buffer:

  UBIAD1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  UBIAD1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  UBIAD1 antibody is human, mouse and rat reactive.

• Symbol:

  UBIAD1

• NCBI Official Name:

  UbiA prenyltransferase domain containing 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  McGarvey TW, Nguyen T, Tomaszewski JE, et al. Isolation and characterization of TERE1 gene, a gene down-regulated in transitional cell carcinoma of the bladder. Oncogene 2001; 20:1042-51.

• Background Reference 02:

  Fredericks WJ, McGarvey T, Wang H, et al. The bladder tumor suppressor protein TERE1 (UBIAD1) modulates cell cholesterol: implications for tumor progression. DNA Cell Biol. 2011; 30:851-64.

• Background Reference 03:

  Orr A, Dube MP, Marcadier J, et al. Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy. PLoS One 2007; 2:e685.

• Other Product Names:

  UBIAD1 Antibody: SCCD, TERE1, UbiA prenyltransferase domain-containing protein 1, Transitional epithelial response protein 1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  7019551

• Physical Properties:

  Liquid