TERF2 Antibody

• Background:

  The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1) . TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2) . TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3) . TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5) .

• NCBI Gene ID:

  7014

• Swiss Prot:

  Q15554

• Accession Number:

  NP_005643

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  TERF2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (92%)

• Buffer:

  TERF2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TERF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TERF2 antibody is human specific.

• Symbol:

  TERF2

• Positive Control 2:

  Cat. No. 10-401 - Human Kidney Tissue Slide

• NCBI Official Name:

  Telomeric repeat binding factor 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Broccoli D, Smogorzewska A, Chong L, et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 1997; 17:231-5.

• Background Reference 02:

  Bilaud T, Brun C, Ancelin K, et al. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 1997; 17:236-9.

• Background Reference 03:

  Van Steensel B and Smogorzewska A. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92:401-13.

• Background Reference 04:

  Matsutani N, Yokozaki H, Tahara E, et al. Expression of TRF1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. Int. J. Oncol. 2001; 19:507-12.

• Other Product Names:

  TERF2 Antibody: TRF2, TRBF2, TRF2, Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2

• Tested Applications:

  ELISA, WB, IHC-P

• Protein ID:

  429535832

• Physical Properties:

  Liquid