RegisterLogin

TERF2 Antibody

CAT: 0223-7727-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7727-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
The telomeric repeat binding factor family (TERF1 and TERF2) plays a key role in cellular immortalization and cellular senescence (1) . TERF2, as a component of the telomere nucleoprotein complex, is present at telomeres in metaphase of the cell cycle (2) . TERF2 is a second negative regulator of telomere length and binds as a dimer to TTAGGG repeats at ends of chromosomes (telomeres), where it blocks inappropriate activation of the ATM/p53 pathway (2,3) . TERF1 negatively regulates telomere elongation, while TERF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression (4,5) .
NCBI Gene ID
7014
Swiss Prot
Q15554
Accession Number
NP_005643
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
TERF2 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (92%)
Buffer
TERF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TERF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
TERF2 antibody is human specific.
Symbol
TERF2
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Telomeric repeat binding factor 2
NCBI Organism
Homo sapiens
Background Reference 01
Broccoli D, Smogorzewska A, Chong L, et al. Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat. Genet. 1997; 17:231-5.
Background Reference 02
Bilaud T, Brun C, Ancelin K, et al. Telomeric localization of TRF2, a novel human telobox protein. Nat. Genet. 1997; 17:236-9.
Background Reference 03
Van Steensel B and Smogorzewska A. TRF2 protects human telomeres from end-to-end fusions. Cell 1998; 92:401-13.
Background Reference 04
Matsutani N, Yokozaki H, Tahara E, et al. Expression of TRF1 and 2 and TRF1-interacting nuclear protein 2 in human gastric carcinomas. Int. J. Oncol. 2001; 19:507-12.
Other Product Names
TERF2 Antibody: TRF2, TRBF2, TRF2, Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2
Tested Applications
ELISA, WB, IHC-P
Protein ID
429535832
Physical Properties
Liquid

Related Products

CatalogName
7727PTERF2 Peptide
13-047TERF1 Antibody
46-480TERF1 Antibody
43-545TERF1 / TRF1 Antibody
46-480PTERF1 Peptide
43-545PTERF1 / TRF1 Peptide
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
XG-6108Fibrinogen Antibody

Alternative Products

CatalogName
A55300-100UGTERF2 Antibody

Popular Products