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FMR1 Antibody

CAT: 0223-7707-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7707-01Size:0.02 mg
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Background
Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1) . FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2) . A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1) . Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3) .
NCBI Gene ID
2332
Swiss Prot
Q06787
Accession Number
NP_002015
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
FMR1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
FMR1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
FMR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
FMR1 antibody is human, mouse and rat reactive. Multiple isoforms of FMR1 are known to exist.
Symbol
FMR1
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Fragile X mental retardation 1
NCBI Organism
Homo sapiens
Background Reference 01
Jin P and Warren ST. Understanding the molecular basis of fragile X syndrome. Hum. Mol. Genet. 2000; 9:901-8.
Background Reference 02
Corbin F, Bouillon M, Fortin A, et al. The fragile X mental retardation protein is associated with poly (A) + mRNA in actively translating polyribosomes. Hum. Mol. Genet. 1997; 1465-72.
Background Reference 03
Lu C, Lin L, Tan H, et al. Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Hum. Mol. Genet. 2012; 5039-47.
Other Product Names
FMR1 Antibody: Fragile X mental retardation protein 1, FMRP
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4503765
Physical Properties
Liquid

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