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SUZ12 Antibody

CAT: 0223-7701-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7701-01Size:0.02 mg
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Background
The Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation and oncogenesis (1) . SUZ12 (suppressor of zeste 12) is a 90 - 95 kDa member of the polycomb group of transcriptional regulators (2) . It is part of a transcription repression complex termed PRC2 (Polycomb repressive complex 2) that methylates histones in the nucleus, resulting in homeotic (pattern-inducing) gene silencing. It contains one C2H2-type zinc finger region and a C-terminal VEFS-box (3,4) . SUZ12 is overexpressed in breast and colon cancer. SUZ12 may be a cause of endometrial stromal tumors (5) .
NCBI Gene ID
23512
Swiss Prot
Q15022
Accession Number
NP_056170
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
SUZ12 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1304 - Human Liver Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (79%)
Buffer
SUZ12 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SUZ12 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SUZ12 antibody is human specific.
Symbol
SUZ12
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
SUZ12 polycomb repressive complex 2 subunit
NCBI Organism
Homo sapiens
Background Reference 01
Kirmizis A, Bartley SM, Kuzmichev A, et al. Silencing of human polycomb target genes is associated with methylation of Histone H3 Lys 27. Genes Dev. 2004; 18:1592-605.
Background Reference 02
Pasini D, Bracken AP, Hansen JB, et al. The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell. Biol. 2007; 27:3769-79.
Background Reference 03
Cao R and Zhang Y. SUZ12 is required for both the Histone methyltransferase activity and the silencing function of the EED-EZH2 complex. Mol. Cell 2004; 15:57-67.
Background Reference 04
Pasini D, Bracken AP, Jensen MR, et al. SUZ12 is essential for mouse development and for EZH2 Histone methyltransferase activity. EMBO J. 2004; 23:4061-71.
Other Product Names
SUZ12 Antibody: CHET9, JJAZ1, CHET9, KIAA0160, Polycomb protein SUZ12, Chromatin precipitated E2F target 9 protein, ChET 9 protein
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
197333809
Physical Properties
Liquid

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