GLIPR1L2 Antibody

• Background:

  The GLIPR1-like 2 protein (GLIPR1L2) gene is part of a p53 target gene cluster that includes the related proteins GLIPR1 and GLIPR1L2 (2) . GLIPR1L2 is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1) . GLIPR1 is a tumor suppressor whose expression is regulated by p53 (3) . Deletions of the GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster have been observed in some multiple myeloma samples, suggesting that these proteins may also be involved in the pathogenesis of multiple myeloma (4) .

• NCBI Gene ID:

  144321

• Swiss Prot:

  Q4G1C9

• Accession Number:

  NP_001257325

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  GLIPR1L2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1313 - Human Testis Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  GLIPR1L2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  GLIPR1L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  GLIPR1L2 antibody is human specific. At least two isoforms of GLIPR1L2 are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.

• Symbol:

  GLIPR1L2

• Positive Control 2:

  Cat. No. 11-701 - Human Testis Tissue Slide

• NCBI Official Name:

  GLI pathogenesis-related 1 like 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ren C, Ren CH, Li L, et al. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster. Genomics 2006; 88:163-72.

• Background Reference 02:

  Murphy EV, Zhang Y, Zhu W, et al. The human glioma pathogenesis-related protein is structurally related to pathogenesis-related proteins and its gene is expressed specifically in brain tumors. Gene 1995; 159:131-5.

• Background Reference 03:

  Ren C, Li L, Yang G, et al. RTVP-1, a tumor suppressor inactivated by methylation in prostate cancer. Cancer Res. 2004; 64:969-76.

• Background Reference 04:

  Tam M, Lin P, Hu P, et al. Examining hedgehog pathway genes GLI3, SHH, and PTCH1 and the p53 target GLIPR1/GLIPR1L1/GLIPR1L2 gene cluster using fluorescence in situ hibridization uncovers GLIPR1/GLIPR1L1/GLIPR1L2 deletion in 9% of patients with multiple myeloma. J. Assoc. Genet. Technol. 2010; 36:111-4.

• Other Product Names:

  GLIPR1L2 Antibody: GLIPR1-like protein 2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  394025727

• Physical Properties:

  Liquid