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ULK4 Antibody

CAT: 0223-7587-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7587-01Size:0.02 mg
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Background
ULK4 belongs to the Ser/Thr protein kinase superfamily and plays a role in the ATP-dependent phosphorylation of target proteins (1) . Knockout of ULK genes results in a severe defect in the autophagy pathway (2) . ULK4, like the other Unc-51-like kinases such as ULK1, ULK2 and ULK3, is highly conserved among eukaryotes (3) . ULK4 has been implicated as a gene involved in the development of hydrocephalus (3) . This neurologic disorder is being used in animal models to elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans (4) .
NCBI Gene ID
54986
Swiss Prot
Q96C45
Accession Number
NP_060356
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
ULK4 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Concentration
1 mg/mL
Buffer
ULK4 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ULK4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
ULK4 antibody is human and mouse reactive. Multiple isoforms of ULK4 are known to exist.
Symbol
ULK4
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Unc-51 like kinase 4
NCBI Organism
Homo sapiens
Background Reference 01
Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 2007; 12:209–18.
Background Reference 02
Lee EJ and Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95.
Background Reference 03
Zhou X, Babu JR, da Silva S, et al. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc. Natl. Acad. Sci. USA 2007; 104:5842-7.
Background Reference 04
Vogel P, Read RW, Hansen GM, et al. Congenital hydrocephalus in genetically engineered mice. Vet. Pathol. 2012; 49:166-81.
Other Product Names
ULK4 Antibody: FAM7C1, REC01035Unc-51-like kinase 4
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
151301204
Physical Properties
Liquid

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