ULK2 Antibody

• Background:

  ULK2 Antibody: ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.

• NCBI Gene ID:

  9706

• Swiss Prot:

  Q8IYT8

• Accession Number:

  NP_055498

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy

• Purification:

  ULK2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1303 - Human Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (82%)

• Buffer:

  ULK2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ULK2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  At least two isoforms of ULK2 are known to exist; this antibody will detect both isoforms. ULK2 antibody is predicted to not cross-react with ULK1.

• Symbol:

  ULK2

• Positive Control 2:

  Cat. No. 10-301 - Human Brain Tissue Slide

• NCBI Official Name:

  Unc-51-like kinase 2 (C. elegans)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Suzuki K, Kubota Y, Sekito T, et al. Hierarchy of Atg proteins in pre-autophagosomal structure organization. Genes to Cells 2007; 12:209–18.

• Background Reference 02:

  Lee EJ and Tournier C. The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy. Autophagy 2011; 7:689-95.

• Background Reference 03:

  Jung CH, Jun CB, Ro SH, et al. ULK-ATG13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell 2009; 20:1992-2003.

• Background Reference 04:

  Zhou X, Babu JR, da Silva S, et al.Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proc. Natl. Acad. Sci. USA 2007; 104:5842-7.

• Other Product Names:

  ULK2 Antibody: ATG1B, Unc51.2, KIAA0623, Unc-51-like kinase 2

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  217330557

• Physical Properties:

  Liquid