COMMD7 Antibody

• Background:

  COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1) . It associates with the NF-kB complex and suppresses its transcriptional activity (2) . COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3) . COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4) . COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4) .

• NCBI Gene ID:

  149951

• Swiss Prot:

  Q86VX2

• Accession Number:

  NP_444269

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle

• Purification:

  COMMD7 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1406 - Mouse Spleen Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (95%)

• Buffer:

  COMMD7 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  COMMD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.

• Symbol:

  COMMD7

• Positive Control 2:

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name:

  COMM domain containing 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.

• Background Reference 02:

  Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.

• Background Reference 03:

  Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1) . Biochemistry 2007; 46:3116-28.

• Background Reference 04:

  Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412.

• Other Product Names:

  COMMD7 Antibody: C20orf92, dJ1085F17.3, C20orf92, COMM domain-containing protein 7

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  151101369

• Physical Properties:

  Liquid