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COMMD7 Antibody

CAT: 0223-7541-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7541-01Size:0.02 mg
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Background
COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1) . It associates with the NF-kB complex and suppresses its transcriptional activity (2) . COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3) . COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4) . COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4) .
NCBI Gene ID
149951
Swiss Prot
Q86VX2
Accession Number
NP_444269
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
COMMD7 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Buffer
COMMD7 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
COMMD7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.
Symbol
COMMD7
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
COMM domain containing 7
NCBI Organism
Homo sapiens
Background Reference 01
Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.
Background Reference 02
Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.
Background Reference 03
Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1) . Biochemistry 2007; 46:3116-28.
Background Reference 04
Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412.
Other Product Names
COMMD7 Antibody: C20orf92, dJ1085F17.3, C20orf92, COMM domain-containing protein 7
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
151101369
Physical Properties
Liquid

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