AIMP2 Antibody

• Background:

  AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1) . It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2) . AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3) . Finally, AIMP2 has been suggested to function as a tumor suppressor (4) .

• NCBI Gene ID:

  7965

• Swiss Prot:

  Q13155

• Accession Number:

  NP_006294

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis

• Purification:

  AIMP2 antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1201 - HeLa Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  AIMP2 antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  AIMP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.

• Symbol:

  AIMP2

• NCBI Official Name:

  Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Quevillon S, Robinson JC, Berthonneau E, et al. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J. Mol. Biol. 1999; 285:183-95.

• Background Reference 02:

  Ko HS, von Coelln R, Sriram SR, et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neruosci. 2005; 25:7968-78.

• Background Reference 03:

  Choi JW, Kim DG, Park MC, et al. AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. J. Cell Sci. 2009; 122:2710-5.

• Background Reference 04:

  Choi JW, UM JY, Kundu JK, et al. Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. Carcinogenesis 2009; 30:1638-44.

• Other Product Names:

  AIMP2 Antibody: P38, JTV1, JTV-1, PRO0992, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  11125770

• Physical Properties:

  Liquid