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SOGA1 Antibody

CAT: 0223-7487-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7487-01Size:0.02 mg
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Background
The recently identified protein suppressor of glucose by autophagy protein 1 (SOGA1) has been found to be involved in the regulation of autophagy (1) . SOGA1 is thought to contribute to adiponectin-mediated insulin-dependent inhibition of autophagy during the activation of adenosine monophosphate kinase (AMPK) (1,2) . SOGA1 contains an internal signal peptide that enables the secretion of a circulating fragment of SOGA1, providing a surrogate marker for intracellular SOGA1 levels (2) . Knockdown of SOGA1 elevated glucose production in primary hepatocytes indicates that SOGA1 is an inhibitor of glucose production. It thus might be useful as a novel therapeutic target for diabetes (3) .
NCBI Gene ID
140710
Swiss Prot
O94964
Accession Number
NP_954650
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy
Purification
SOGA1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (93%)
Buffer
SOGA1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SOGA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SOGA1 antibody is human specific. At least four isoforms of SOGA1 are known to exist.
Symbol
SOGA1
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Suppressor of glucose, autophagy associated 1
NCBI Organism
Homo sapiens
Background Reference 01
Cowherd RB, Asmar MM, Alderman JM, et al. Adiponectin lowers glucose production by increasing SOGA. Am. J. Pathol. 2010; 177:1936-45.
Background Reference 02
Madi T, Balamurugan K, Bombardi R, et al. The determination of tissue-specific DNA methylation patterns in forensic biofluids using bisulfite modification and pyrosequencing. Electrophoresis 2012; 33:1736-45.
Background Reference 03
Forbes JM. The physiological deadlock between AMPK and gluconeogenesis: SOGA, a novel protein, may provide the key. Am. J. Pathol. 2010; 177:1600-2.
Other Product Names
SOGA1 Antibody : SOGA, KIAA0889, C20orf117, SOGA, Protein SOGA1, SOGA family member 1, 80-kDa SOGA fragment
Tested Applications
ELISA, WB, IF
Protein ID
66773344
Physical Properties
Liquid

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