ERAP2 Antibody

• Background:

  The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2) . Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1) . Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3) .

• NCBI Gene ID:

  64167

• Swiss Prot:

  Q6P179

• Accession Number:

  NP_071745

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Innate Immunity

• Purification:

  ERAP2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1316 - Human Ovary Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine: (75%)

• Buffer:

  ERAP2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ERAP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  ERAP2 antibody is human reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1.

• Symbol:

  ERAP2

• NCBI Official Name:

  Endoplasmic reticulum aminopeptidase 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Saveanu L, Carroll O, Lindo V, et al. Concerted peptide trimming by EARP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat. Immunol. 2005; 6:689-97.

• Background Reference 02:

  Saric T, Chang SC, Hattori A, et al. An IFN-gamma induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat. Immunol. 2002; 3:1169-76.

• Background Reference 03:

  Cifaldi L, Romania P, Lorenzi S, et al. Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer. Int. J. Mol. Sci. 2012; 13:8338-52

• Other Product Names:

  ERAP2 Antibody : LRAP, L-RAP, LRAP, Endoplasmic reticulum aminopeptidase 2, Leukocyte-derived arginine aminopeptidase

• Tested Applications:

  ELISA, WB

• Protein ID:

  11641261

• Physical Properties:

  Liquid