ARSB Antibody

CAT: 0223-7465-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7465-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1) . ARSB localizes to the lysozyme as well as to the extracellular matrix (2) . Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4) .
NCBI Gene ID
411
Swiss Prot
P15848
Accession Number
NP_000037
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
ARSB Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1412 - Mouse Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
ARSB Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ARSB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.
Symbol
ARSB
Positive Control 2
Cat. No. 1412 - Mouse Cerebellum Tissue Lysate
Positive Control 3
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Arylsulfatase B
NCBI Organism
Homo sapiens
Background Reference 01
Wasserman SI and Austen KF. Arylsulfatase B of human lung. Isolation, characterization, and interaction with slow-reacting substance of anaphylaxis. J. Clin. Invest. 1976; 57:738-44.
Background Reference 02
Mitsunaga-Nakatsubo K, Kusunoki S, Kawakami H, et al. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. Med. Mol. Morphol. 2009; 42:63-9.
Background Reference 03
Valayannopoulos V, Nicely H, Harmatz P, et al. Mucopolysaccharidosis VI. Orphanet. J. Rare Dis. 2010; 5:5.
Background Reference 04
Harmatz P, Whitley CB, Waber L, et al. Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) . J. Pediatr. 2004; 144:574-80.
Other Product Names
ARSB Antibody : ASB, G4S, MPS6, Arylsulfatase B, N-acetylgalactosamine-4-sulfatase, ASB
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
38569405
Physical Properties
Liquid

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