ARSB Antibody

• Background:

  Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1) . ARSB localizes to the lysozyme as well as to the extracellular matrix (2) . Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4) .

• NCBI Gene ID:

  411

• Swiss Prot:

  P15848

• Accession Number:

  NP_000037

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  ARSB Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1412 - Mouse Lung Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  ARSB Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ARSB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist; this antibody only recognizes the longest isoform.

• Symbol:

  ARSB

• Positive Control 2:

  Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

• Positive Control 3:

  Cat. No. 10-101 - Human Lung Tissue Slide

• NCBI Official Name:

  Arylsulfatase B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wasserman SI and Austen KF. Arylsulfatase B of human lung. Isolation, characterization, and interaction with slow-reacting substance of anaphylaxis. J. Clin. Invest. 1976; 57:738-44.

• Background Reference 02:

  Mitsunaga-Nakatsubo K, Kusunoki S, Kawakami H, et al. Cell-surface arylsulfatase A and B on sinusoidal endothelial cells, hepatocytes, and Kupffer cells in mammalian livers. Med. Mol. Morphol. 2009; 42:63-9.

• Background Reference 03:

  Valayannopoulos V, Nicely H, Harmatz P, et al. Mucopolysaccharidosis VI. Orphanet. J. Rare Dis. 2010; 5:5.

• Background Reference 04:

  Harmatz P, Whitley CB, Waber L, et al. Enzyme replacement therapy in mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) . J. Pediatr. 2004; 144:574-80.

• Other Product Names:

  ARSB Antibody : ASB, G4S, MPS6, Arylsulfatase B, N-acetylgalactosamine-4-sulfatase, ASB

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  38569405

• Physical Properties:

  Liquid