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DDC Antibody

CAT: 0223-7447-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7447-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1) . It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2) . It can form a homodimer and is expressed in the central nervous system (2) . DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4) . Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4) .
NCBI Gene ID
1644
Swiss Prot
P20711
Accession Number
NP_000781
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
DDC Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (92%), Guinea pig: (77%), Pig: (77%)
Buffer
DDC Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DDC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
DDC antibody is human, mouse and rat reactive.
Symbol
DDC
Positive Control 2
Cat. No. 10-101 - Human Lung Tissue Slide
NCBI Official Name
Dopa decarboxylase (aromatic L-amino acid decarboxylase)
NCBI Organism
Homo sapiens
Background Reference 01
Berry MD, Juorio AV, Li XM, et al. Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem. Res. 1996; 21:1075-87.
Background Reference 02
Sumi-Ichinose C, Ichinose H, Takahashi E, et al. Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and Serotonin biosynthesis. Biochemistry 1992; 31:2229-38.
Background Reference 03
Haycock JW, Becker L, Ang L, et al. Marked disparity between age-related changes in dopamine and other presynaptic dopaminergic markers in human striatum. J. Neurochem. 2003; 87:574-85.
Background Reference 04
Chang YT, Sharma R, Marsh JL, et al. Levodopa-responsive aromatic L-amino acid decarboxylase deficiency. Ann. Neurol. 2004; 55:435-8.
Other Product Names
DDC Antibody : AADC, AADC, Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4503281
Physical Properties
Liquid

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