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KLK4 Antibody

CAT: 0223-7445-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7445-01Size:0.02 mg
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Background
Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes having diverse physiological functions (1) . Kallikrein 4 (KLK4), also known as prostase or EMSP1 (enamel matrix serine protease 1), contains one peptidase S1 domain and the expression in prostate is regulated by hormone (1,2) . Many kallikreins are implicated in carcinogenesis and have potential as novel cancer and other disease biomarkers (3) . KLK4 may have additional roles such as functioning as one of the two major enamel proteases identified that process enamel matrix proteins. Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) (4) .
NCBI Gene ID
9622
Swiss Prot
Q9Y5K2
Accession Number
NP_004908
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
KLK4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1305 - Human Kidney Tissue Lysate
Concentration
1 mg/mL
Buffer
KLK4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KLK4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
KLK4 antibody is human specific. At least three isoforms of KLK4 are known to exist.
Symbol
KLK4
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
Kallikrein-related peptidase 4
NCBI Organism
Homo sapiens
Background Reference 01
Stephenson SA, Verity K, Ashworth LK, et al. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4. J. Biol. Chem. 1999; 274:23210-4.
Background Reference 02
Myers SA and Clements JA. Kallikrein 4 (KLK4), a new member of the human kallikrein gene family is up-regulated by estrogen and progesterone in the human endometrial cancer cell line, KLE. J. Clin. Endocrinol. Metab. 2001; 86:2323-6.
Background Reference 03
Kontos CK, Chantzis D, Papadopoulos IN, et al. Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients. Cancer Lett. 2013; 330:106-12
Background Reference 04
Shimizu-Okabe C, Yousef GM, Diamandis EP, et al. Expression of the kallikrein gene family in normal and Alzheimer's disease. Neuroreport 2001; 12:27447-51.
Other Product Names
KLK4 Antibody : ARM1, EMSP, PSTS, AI2A1, EMSP1, KLK-L1, PRSS17, kallikrein, Kallikrein-4, Enamel matrix serine proteinase 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
89142741
Physical Properties
Liquid

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