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B2M Antibody

CAT: 0223-7439-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7439-01Size:0.02 mg
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Background
B2M Antibody: Beta2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system (1,2) . B2M is involved in the presentation of peptide antigens to the immune system and plays a critically important role in immune system function (3) . It is expressed on nearly all nucleated cells and contains one Ig-like C1-type (immunoglobulin-like) domain (2,3) . Mutations in the Beta 2-microglobulin gene can enhance the progression of malignant melanoma and osteoarthropathy (4,5) .
NCBI Gene ID
567
Swiss Prot
P61769
Accession Number
NP_004039
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
B2M Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (83%), Rat: (83%)
Buffer
B2M Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
B2M antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
B2M antibody is human reactive.
Symbol
B2M
NCBI Official Name
Beta-2-microglobulin
NCBI Organism
Homo sapiens
Background Reference 01
Krangel MS, Orr HT, and Strominger JL. Assembly and maturation of HLA-A and HLA-B antigens in vivo. Cell 1979; 18:979-91.
Background Reference 02
Skjodt K, Welinder KG, Crone M, et al. Isolation and characterization of chicken and turkey beta 2-microglobulin. Mol. Immunol. 1986; 23:1301-9.
Background Reference 03
Ohashi K. Pathogenesis of beta2-microglobulin amyloidosis. Pathol. Int. 2001; 51:1-10.
Background Reference 04
Blum C, Graham A, Yousefzadeh M, et al. The expression ratio of Map7/B2M is prognostic for survival in patients with stage II colon cancer. Int. J. Oncol. 2008; 33:579-84.
Other Product Names
B2M Antibody: Beta-2-microglobulin
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4757826
Physical Properties
Liquid

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