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TLX3 Antibody

CAT: 0223-7375-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7375-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL) .
NCBI Gene ID
30012
Swiss Prot
O43711
Accession Number
NP_066305
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
TLX3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1306 - Human Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TLX3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
TLX3 antibody is predicted to not cross-react with other TLX proteins.
Symbol
TLX3
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
T-cell leukemia homeobox 3
NCBI Organism
Homo sapiens
Background Reference 01
Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Background Reference 02
Patterson KD and Kried PA. Hox11-family genes XHox11 and XHox11L2 in xenopus: XHoxL2 expression is restricted to a subset of the primary sensory neurons. Dev. Dyn. 1999; 214:34-43.
Background Reference 03
Cheng L, Arata A, Mizuguchi R, et al. Tlx3 and Tlx1 are post-mitotic selector genes determining the glutamatergic over GABAergic cell fates. Nat. Neurosci. 2004; 7:510-7.
Background Reference 04
Cheng L, Samad OA, Xu Y, et al. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat. Neurosci. 2005; 8:1510-5.
Other Product Names
TLX3 Antibody: RNX, HOX11L2, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
50355978
Physical Properties
Liquid

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