TLX3 Antibody

• Background :

  TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL) .

• NCBI Gene ID :

  30012

• Swiss Prot :

  O43711

• Accession Number :

  NP_066305

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Stem Cell

• Purification :

  TLX3 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1306 - Human Spleen Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  TLX3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  TLX3 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

• Fragment :

  IgG

• Specificity :

  TLX3 antibody is predicted to not cross-react with other TLX proteins.

• Symbol :

  TLX3

• Positive Control 2 :

  Cat. No. 10-901 - Human Spleen Tissue Slide

• NCBI Official Name :

  T-cell leukemia homeobox 3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.

• Background Reference 02 :

  Patterson KD and Kried PA. Hox11-family genes XHox11 and XHox11L2 in xenopus: XHoxL2 expression is restricted to a subset of the primary sensory neurons. Dev. Dyn. 1999; 214:34-43.

• Background Reference 03 :

  Cheng L, Arata A, Mizuguchi R, et al. Tlx3 and Tlx1 are post-mitotic selector genes determining the glutamatergic over GABAergic cell fates. Nat. Neurosci. 2004; 7:510-7.

• Background Reference 04 :

  Cheng L, Samad OA, Xu Y, et al. Lbx1 and Tlx3 are opposing switches in determining GABAergic versus glutamatergic transmitter phenotypes. Nat. Neurosci. 2005; 8:1510-5.

• Other Product Names :

  TLX3 Antibody: RNX, HOX11L2, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  50355978

• Physical Properties :

  Liquid