TLX1 Antibody

CAT: 0223-7361-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7361-01Size:0.02 mg
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Background
TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.
NCBI Gene ID
3195
Swiss Prot
P31314
Accession Number
NP_005512
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
TLX1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1406 - Mouse Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
TLX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TLX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins.
Symbol
TLX1
Positive Control 2
Cat. No. 10-901 - Human Spleen Tissue Slide
NCBI Official Name
T-cell leukemia homeobox 1
NCBI Organism
Homo sapiens
Background Reference 01
Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.
Background Reference 02
Dube ID, Kamel-Reid S, Yuan CC, et al. A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t (10;14) . Blood 1991; 78:2996-3003.
Background Reference 03
Hatano M, Roberts CW, Minden M, et al. Deregulation of a homeobox gene, Hox11, by the t (10;14) in T cell leukemia. Science 1991; 253:79-82.
Background Reference 04
Roberts CW, Shutter JR, Korsmeyer SJ et al. Hox11 controls the genesis of the spleen. Nature 1994; 368:747-9.
Other Product Names
TLX1 Antibody: TCL3, HOX11, TCL3, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11
Tested Applications
ELISA, WB, IHC-P
Protein ID
5031757
Physical Properties
Liquid

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