TLX2 Antibody

• Background:

  TLX2 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX2, also known as homeobox11-like 1 (HOX11L1), is a DNA-binding nuclear transcription factor that appears to be crucial for the development of the peripheral nervous system. TLX2 is a downstream target of regulation by both PHOX2A and PHOX2B proteins during intestinal neuronal differentiation. In humans, loss-of-function of TLX2 may play a role in tumorigenesis of gastrointestinal stromal tumors.

• NCBI Gene ID:

  3196

• Swiss Prot:

  O43763

• Accession Number:

  NP_057254

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  TLX2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration:

  1 mg/mL

• Buffer:

  TLX2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TLX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TLX2 antibody is predicted to not cross-react with other TLX proteins.

• Symbol:

  TLX2

• NCBI Official Name:

  T-cell leukemia homeobox 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5.

• Background Reference 02:

  Puliti A, Cinti R, Betsos N, et al. HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1>p12 and mouse chromosome 6C3-D1. Cytogenet. Cell Genet. 1999; 84:115-7.

• Background Reference 03:

  Borghini S, Di Duca M, Santamaria G, et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur. J. Human Genet. 2007; 15:848-55.

• Background Reference 04:

  Borghini S, Bachetti T, Fava M, et al. The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural crest derived cells. Biochem. J. 2006; 395:355-61.

• Other Product Names:

  TLX2 Antibody: NCX, HOX11L1, NCX, T-cell leukemia homeobox protein 2, Homeobox protein Hox-11L1

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  7706621

• Physical Properties:

  Liquid