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WAC Antibody

CAT: 0223-7293-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7293-01Size:0.02 mg
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Background
WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
NCBI Gene ID
51322
Swiss Prot
Q9BTA9
Accession Number
NP_057712
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
WAC Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1313 - Human Testis Tissue Lysate
Concentration
1 mg/mL
Buffer
WAC Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
WAC antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
At least two isoforms of WAC are known to exist; this antibody will detect the larger isoform.
Symbol
WAC
NCBI Official Name
WW domain containing adaptor with coiled-coil
NCBI Organism
Homo sapiens
Background Reference 01
Xu GM and Arnaout MA. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics 2002; 79:87-94.
Background Reference 02
Zhang F and Yu X. WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription. Mol. Cell 2011; 41:384-97.
Other Product Names
WAC Antibody: Wwp4, BM-016, PRO1741, KIAA1844, WW domain-containing adapter protein with coiled-coil
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
18379328
Physical Properties
Liquid

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