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SHISA4 Antibody

CAT: 0223-7277-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7277-01Size:0.02 mg
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Background
SHISA4 Antibody: SHISA4 plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region. Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling. Shisa physically interacted with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER and inhibited their posttranslational maturation and trafficking to the cell surface. Loss of Shisa function sensitized the neuroectoderm to Wnt signaling and suppressed head formation during gastrulation.
NCBI Gene ID
149345
Swiss Prot
Q96DD7
Accession Number
NP_937792
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
SHISA4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
SHISA4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SHISA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
SHISA4 antibody is predicted to not cross-react with other SHISA protein family members.
Symbol
SHISA4
NCBI Official Name
Shisa homolog 4 (Xenopus laevis)
NCBI Organism
Homo sapiens
Background Reference 01
Furushima K, Yamamoto A, Nagano T, et al. Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings. Dev. Biol. 2007; 306:480-92.
Background Reference 02
Pei J and Grishin NV. Unexpected diversity in Shisa-like proteins suggests the importance of their roles as transmembrane adaptors. Cell Signal. 2012; 24:758-69.
Background Reference 03
Yamamoto A, Nagano T, Takehara S, et al. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Cell 2005; 120:223-35.
Other Product Names
SHISA4 Antibody: TMEM58, C1orf40, TMEM58, UNQ583/PRO1153, Protein shisa-4, Transmembrane protein 58
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
269973884
Physical Properties
Liquid

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