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KREMEN2 Antibody

CAT: 0223-7263-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7263-01Size:0.02 mg
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Background
KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
NCBI Gene ID
79412
Swiss Prot
Q8NCW0
Accession Number
NP_757384
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
7263
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Independent Antibody Validation in Cell lines (Figure 1) shows similar KREMEN2 expression profile in human, mouse and rat cell lines detected by two independent anti-KREMEN2 antibodies that recognize different epitopes, 7263 against C-terminus domain and 64-235 against central domain. KREMEN2 proteins are detected in most of the tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines7263 64-235
Field of Research
Stem Cell
Purification
KREMEN2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KREMEN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Fragment
IgG
Specificity
Multiple isoforms of KREMEN2 are known to exist. KREMEN2 antibody is predicted to not cross-react with other Kremen protein family members.
Isoform
Human KREMEN2 has 6 isoforms, including isoform 1 (462aa, 49kD), isoform 2 (424aa, 45kD), isoform 3 (420aa, 44kD), isoform 4 (399aa, 42kD), isoform 5 (423aa, 45kD), and isoform 6 (381aa, 40kD) . Mouse KREMEN2 has one isoform (461aa, 49kD) and rat KREMEN2 also has one isoform (468aa, 50kD) . 7263 can detect human, mouse and rat.
Symbol
KREMEN2
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Kringle containing transmembrane protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Nakamura et al. Biochim. Biophys. Acta. 2001; 1518:63-72.
Background Reference 02
Mao et al. Nature 2002; 417:664-7.
Background Reference 03
Li et al. Fertil. Steril. 2008; 90:1470-9.
Background Reference 04
Schulze et al. PLoS 2010; 5:e10309.
Other Product Names
KREMEN2 Antibody: KRM2, KRM2, Kremen protein 2, Dickkopf receptor 2
Tested Applications
ELISA, WB, ICC
Protein ID
27437008
Physical Properties
Liquid

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