CCNT1 Antibody

• Background :

  CCNT1 Antibody: Cyclins function as regulators of CDK kinases and exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin-T1 protein (CCNT1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNT1 tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing CCNT1 and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. CCNT1 and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.

• NCBI Gene ID :

  904

• Swiss Prot :

  O60563

• Accession Number :

  NP_001231

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  CCNT1 Antibody is affinity chromatography purified via peptide column.

• Positive Control :

  Cat. No. 1463 - Rat Brain Tissue Lysate

• Concentration :

  1 mg/mL

• Buffer :

  CCNT1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  CCNT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight :

  Predicted: 80 kDa

• Fragment :

  IgG

• Symbol :

  CCNT1

• NCBI Official Name :

  Cyclin T1

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Uhlmann F, Bouchoux C, and Lopez-Aviles S. A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited. Philos. Trans. R. Soc. Lond. B. biol. Sci. 2011; 366:3572-83.

• Background Reference 02 :

  Wei P, Garber ME, Fang SM, et al. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 1998; 92:451-62.

• Background Reference 03 :

  Mancebo HS, Lee G, Flygare J, et al. P-TEFb kinase is require for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev. 1997 ; 11 :2633-44.

• Background Reference 04 :

  Majello B and Napolitano G. Control of RNA polymerase II activity by dedicated CTD kinases and phosphatases. Front. Biosci. 2001; 6:D1358-68.

• Other Product Names :

  CCNT1 Antibody: CCNT, CYCT1, HIVE1, Cyclin-T1, CycT1

• Tested Applications :

  ELISA, WB, IHC-P, IF

• Protein ID :

  17978466

• Physical Properties :

  Liquid