RegisterLogin

CCNT1 Antibody

CAT: 0223-7223-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-7223-01Size:0.02 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
CCNT1 Antibody: Cyclins function as regulators of CDK kinases and exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin-T1 protein (CCNT1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNT1 tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing CCNT1 and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. CCNT1 and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.
NCBI Gene ID
904
Swiss Prot
O60563
Accession Number
NP_001231
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
CCNT1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
CCNT1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
CCNT1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 80 kDa
Fragment
IgG
Symbol
CCNT1
NCBI Official Name
Cyclin T1
NCBI Organism
Homo sapiens
Background Reference 01
Uhlmann F, Bouchoux C, and Lopez-Aviles S. A quantitative model for cyclin-dependent kinase control of the cell cycle: revisited. Philos. Trans. R. Soc. Lond. B. biol. Sci. 2011; 366:3572-83.
Background Reference 02
Wei P, Garber ME, Fang SM, et al. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 1998; 92:451-62.
Background Reference 03
Mancebo HS, Lee G, Flygare J, et al. P-TEFb kinase is require for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev. 1997 ; 11 :2633-44.
Background Reference 04
Majello B and Napolitano G. Control of RNA polymerase II activity by dedicated CTD kinases and phosphatases. Front. Biosci. 2001; 6:D1358-68.
Other Product Names
CCNT1 Antibody: CCNT, CYCT1, HIVE1, Cyclin-T1, CycT1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
17978466
Physical Properties
Liquid

Related Products

CatalogName
7223PCCNT1 Peptide
27-803CCNL1 Antibody
55-627CCNB1 Antibody
16-755CCNB1 Antibody
55-520CCNG1 Antibody
60-977CCND1 Antibody
27-300CCNB1 Antibody
15-586CCNA1 Antibody
70-428CCNA1 Antibody
55-622CCNB1 Antibody

Alternative Products

CatalogName
MBS9603821-01CCNT1 Antibody

Popular Products