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TREM1 Antibody

CAT: 0223-7185-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7185-01Size:0.02 mg
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Background
TREM1 Antibody: TREM1 (triggering receptor expressed on myeloid cells 1) is a receptor belonging to the Ig superfamily that amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. It is thought that TREM1 other related TREM proteins such as TREM2 act to modulate the inflammatory response. TREM1 has also been linked to inflammatory bowel disease resulting in enhanced production of TNF, IL-6, IL-8, and MCP-1.
NCBI Gene ID
54210
Swiss Prot
Q9NP99
Accession Number
NP_061113
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
TREM1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (71%)
Buffer
TREM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TREM1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
Predicted: 26 kDa
Fragment
IgG
Symbol
TREM1
NCBI Official Name
Triggering receptor expressed on myeloid cells
NCBI Organism
Homo sapiens
Background Reference 01
Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001; 410:1103-7.
Background Reference 02
Ford JW and McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 2009; 21:38-46
Background Reference 03
Schenk M, Bouchon A, Seibold F, et al. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 2007; 117:3097-106.
Other Product Names
TREM1 Antibody: CD354, TREM-1, Triggering receptor expressed on myeloid cells 1, Triggering receptor expressed on monocytes 1
Tested Applications
ELISA, WB
Protein ID
8924262
Physical Properties
Liquid

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