CRB1 Antibody

• Background:

  CRB1 Antibody: CRB1 (Crumbs homolog 1) plays a role in photoreceptor morphogenesis in the retina. It may maintain cell polarization and adhesion. CRB1 is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. The first identified human homolog, CRB1, is expressed in retina and some parts of the brain, leaving room for another homolog to function in epithelial tissues. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis.

• NCBI Gene ID:

  23418

• Swiss Prot:

  P82279

• Accession Number:

  NP_001180569

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  CRB1 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1308 - Human Small Intestine Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (82%)

• Buffer:

  CRB1 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  CRB1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Calculated Molecular Weight:

  Predicted: 142 kDa

• Fragment:

  IgG

• Specificity:

  Alternatively spliced transcript variants have been observed. CRB1 antibody i spredicted to not cross-react with CRB2.

• Symbol:

  CRB1

• NCBI Official Name:

  Crumbs homolog 1 (Drosophila)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Van de Pavert SA, Kantardzhieva A, Malysheva A, et al. Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J. Cell Sci. 2004; 117:4169-77.

• Background Reference 02:

  Van de Pavert SA, Sanz AS, Aartsen WM, et al. Crb1 is a determinant of retinal apical Muller glia cell features. Glia 2007; 55:1486-97.

• Background Reference 03:

  Den Hollander AI, Johnson K, de Kok YJ, et al. CRB1 has a cytoplasmic domain that is functionally conserved between human and Drosophila. Hum. Mol. Genet. 2001; 10:2767-73.

• Background Reference 04:

  Bujakowska K, Audo I, Mohand-Said S, et al. CRB1 mutations in inherited retinal dystrophies. Hum. Mutat. 2012; 33:306-15.

• Other Product Names:

  CRB1 Antibody: LCA8, RP12, Protein crumbs homolog 1

• Tested Applications:

  ELISA, WB

• Protein ID:

  302370926

• Physical Properties:

  Liquid