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MECR Antibody

CAT: 0223-7151-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7151-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MECR Antibody: The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
NCBI Gene ID
51102
Swiss Prot
Q9BV79
Accession Number
NP_057095
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
MECR Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Buffer
MECR Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
MECR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Calculated Molecular Weight
Predicted: 41 kDa
Fragment
IgG
Specificity
At least two isoforms of MECR are known to exist; this antibody will detect both isoforms.
Symbol
MECR
Positive Control 2
Cat. No. 1403 - Mouse Brain Tissue Lysate
Positive Control 3
Cat. No. 1463 - Rat Brain Tissue Lysate
NCBI Official Name
Mitochondrial trans-2-enoyl-CoA reductase
NCBI Organism
Homo sapiens
Background Reference 01
Masuda N, Yasumo H, Furusawa T, et al. Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors. Gene 1998; 221:225-33.
Background Reference 02
Chen Z, Leskinen H, Liimatta E, et al. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. PLoS One 2009; 4:e5589.
Other Product Names
MECR Antibody: NRBF1, CGI-63, FASN2B, NBRF1, Trans-2-enoyl-CoA reductase, mitochondrial, Nuclear receptor-binding factor 1, HsNrbf-1
Tested Applications
ELISA, WB
Protein ID
67078404
Physical Properties
Liquid

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