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TDGF1 Antibody

CAT: 0223-7099-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7099-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TDGF1 Antibody: Teratocarcinoma-derived growth factor 1 (TDGF1 or Cripto) is a member of the epidermal growth factor-cripto FRL1 cryptic protein family and is involved in the activation of several different signaling pathways during embryonic development and cellular transformation. It is first expressed in the forming mesoderm during gastrulation but later in development the expression is restricted to the truncus arteriosus of the developing heart. This suggests that TDGF1 mediates the progression of epiblastic cells that give rise to the mesoderm. TDGF1 overexpression is characteristic of human gastric and colorectal carcinomas.
NCBI Gene ID
6997
Swiss Prot
P13385
Accession Number
NP_003203
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
TDGF1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1210 - HEK293 Cell Lysate
Concentration
1 mg/mL
Buffer
TDGF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TDGF1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
IgG
Symbol
TDGF1
Positive Control 2
Cat. No. 17-010 - HEK293 Cell Slide
NCBI Official Name
Teratocarcinoma-derived growth factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Brandt R, Normanno N, Gullick WJ, et al. Identification and biological characterization of an epidermal growth factor-related protein: Cripto-1. J. Biol. Chem. 1994; 269:17320-8.
Background Reference 02
Dono R, Scalera L, Pacifico F, et al. The murine Cripto gene: expression during mesoderm induction and early heart morphogenesis. Development 1993; 118:1157-68.
Background Reference 03
Parisi S, D'Andrea D, Lago CT, et al. Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J. Cell Biol. 2003; 163:303-14.
Background Reference 04
Xing PX, Hu XF, Pietersz GA, et al. Cripto: a novel target for antibody-based cancer immunotherapy. Cancer Res. 2004; 64:4018-23.
Other Product Names
TDGF1 Antibody: CR, CRGF, CRIPTO, Teratocarcinoma-derived growth factor 1, Cripto-1 growth factor
Tested Applications
ELISA, WB, IF
Protein ID
4507425
Physical Properties
Liquid

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