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VNN3 Antibody

CAT: 0223-7057-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7057-01Size:0.02 mg
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Background
VNN3 Antibody: The vanin family is a novel group of ectoenzymes that function in tissue repair and plays a role in oxidative-stress response. As both secreted and membrane proteins, the vanin family members have been implicated as therapeutic targets in inflammatory disease. VNN3 (vascular non-inflammatory molecule 3), also known as Vanin3, is a 501 amino acid GPI-anchored amidohydrolase that is widely expressed and is found at highest levels in blood and liver. Induced by Th17 / Th1 type cytokines, VNN3 converts pantetheine into pantothenic acid. Containing one CN hydrolase domain, VNN3 is encoded by a gene that maps to human chromosome 6q23.2.
NCBI Gene ID
55350
Swiss Prot
Q9NY84
Accession Number
Q9NY84
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
VNN3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1303 - Human Brain Tissue Lysate
Concentration
1 mg/mL
Buffer
VNN3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VNN3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
IgG
Specificity
Multiple isoforms of VNN3 are known to exist.
Symbol
VNN3
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Vanin 3
NCBI Organism
Homo sapiens
Background Reference 01
Granjeaud S, Naquet P and Galland F. An ESTs description of the new Vanin gene family conserved from fly to human. Immunogenetics 1999; 49:964-72.
Background Reference 02
Jansen PA, Kamsteeg M, Rodijk-Olthuis D, et al. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. J. Invest. Dermatol. 2009;129:2167-74.
Background Reference 03
Nitto T, Inoue T and Node K. Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils. Gene 2008; 426:57-64.
Background Reference 04
Martin F, Malergue F, Pitari G, et al. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. Immunogenetics 2001; 53:296-306.
Other Product Names
VNN3 Antibody: HSA238982, Vascular non-inflammatory molecule 3, Vanin-3
Tested Applications
ELISA, WB, IHC-P
Protein ID
88952267
Physical Properties
Liquid

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