DCP2 Antibody

• Background:

  DCP2 Antibody: The removal, or decapping, of eukaryotic mRNA is an important step in the degradation of mRNA. Decapping protein 2 (DCP2) is the major mRNA decapping enzyme in cells. It is a member of the Nudix hydrolases superfamily of proteins that predominantly catalyze the hydrolysis of small nucleoside diphosphate substrates linked to another moiety. DCP2 is widely expressed in multiple tissues at varying levels, with highest expression seen in testis and brain.

• NCBI Gene ID:

  167227

• Swiss Prot:

  Q8IU60

• Accession Number:

  NP_689837

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  DCP2 Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1210 - HEK293 Cell Lysate

• Concentration:

  1 mg/mL

• Buffer:

  DCP2 Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  DCP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  IgG

• Specificity:

  Multiple isoforms of DCP2 are known to exist.

• Symbol:

  DCP2

• Positive Control 2:

  Cat. No. 11-701 - Human Testis Tissue Slide

• NCBI Official Name:

  DCP2 decapping enzyme homolog (S. cerevisiae)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Song MG, Li Y, and Kiledjian M. Multiple mRNA decapping enzymes in mammalian cells. Mol. Cell 2010; 40:423-32.

• Background Reference 02:

  Dunckley T and Parker R. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J. 18:5411-22.

• Background Reference 03:

  Bessman MJ, Frick DN, and O'Handley SF. The MutT proteins of “Nudix" hydrolases, a family of versatile, widely distributed, “housecleaning" enzymes. J. Biol. Chem. 1996; 271:25059-62

• Other Product Names:

  DCP2 Antibody: NUDT20, NUDT20, m7GpppN-mRNA hydrolase, Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20

• Tested Applications:

  ELISA, WB, IF

• Protein ID:

  31542498

• Physical Properties:

  Liquid