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SGSM2 Antibody

CAT: 0223-7035-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-7035-01Size:0.02 mg
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Background
SGSM2 Antibody: Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM2 is a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins.
NCBI Gene ID
9905
Swiss Prot
O43147
Accession Number
NP_055668
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
SGSM2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1362 - Human Cerebellum Tissue Lysate
Concentration
1 mg/mL
Buffer
SGSM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SGSM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
116 kDa
Fragment
IgG
Specificity
Multiple isoforms of SGSM2 are known to exist. SGSM2 antibody is predicted to not cross react with other SGSM family proteins.
Symbol
SGSM2
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Small G protein signaling modulator 2
NCBI Organism
Homo sapiens
Background Reference 01
Bar-Sagi D and Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103:227-38.
Background Reference 02
Colicelli J. Human ras superfamily proteins and related GTPases. Sci. STKE 2004; 250:RE13
Background Reference 03
Yang H, Sasaki T, Minoshima S, et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB) -mediated signaling pathway. Genomics 2007; 90:249-60.
Background Reference 04
Nottingham RM, Ganley IG, Barr FA, et al. RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins. J. Biol. Chem. 2011; 286:33213-22.
Other Product Names
SGSM2 Antibody: RUTBC1, KIAA0397, RUTBC1, Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1
Tested Applications
ELISA, WB, IF
Protein ID
148612795
Physical Properties
Liquid

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