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COH1 Antibody

CAT: 0223-6931-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6931-01Size:0.02 mg
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Background
COH1 Antibody: COH1 (Cohen syndrome protein 1), also known as VPS13B (vacuolar protein sorting-associated protein 13B) or CHS1, belongs to the VPS13 family and may function in vesicle-mediated transport and sorting of proteins within the cell. COH1 is widely expressed and multiple alternatively spliced transcript variants have been observed. Mutations in this gene have been associated with Cohen syndrome. COH1 is a Golgi-localized peripheral membrane protein and plays a critical role in Golgi (re) assembly.
NCBI Gene ID
157680
Swiss Prot
Q7Z7G8
Accession Number
NP_056058
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
COH1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1220 - SK-N-SH Cell Lysate
Concentration
1 mg/mL
Buffer
COH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
COH1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least five alternatively spliced transcript variants have been observed. COH1 detects two isoforms.
Symbol
VPS13B
Positive Control 2
Cat. No. 10-301 - Human Brain Tissue Slide
NCBI Official Name
Vacuolar protein sorting 13 homolog B (yeast)
NCBI Organism
Homo sapiens
Background Reference 01
Velayos-Baeza A, Vettori A, Copley RR, et al. Analysis of the human VPS13 gene family. Genomics 2004; 84:536-49.
Background Reference 02
Kolehmainen J, Black GC, Saarinen A, et al. Cohen syndrome is caused by mutations in a novel gene, COH1, encoding a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport. Am. J. Hum. Genet. 2003; 72:1359-69.
Background Reference 03
Seifert W, Kühnisch J, Maritzen T, et al. Cohen syndrome-associated protein, COH1, is a novel, giant Golgi matrix protein required for Golgi integrity. J. Biol. Chem. 2011; 286:37665-75.
Other Product Names
COH1 Antibody: CHS1, COH1, CHS1, KIAA0532, Vacuolar protein sorting-associated protein 13B, Cohen syndrome protein 1
Tested Applications
ELISA, WB, IF
Protein ID
35493725
Physical Properties
Liquid

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