RAB21 Antibody

CAT: 0223-6927-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6927-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RAB21 Antibody: RAB21 is a member of a subfamily of small GTP-binding protein genes of the Ras superfamily that plays an important role in intracellular vesicular targeting. In non-polarized Caco-2 cells, RAB21 showed a general endoplasmic reticulum (ER) -like localization, while in polarized cells, RAB21 localized to apical vesicles. RAB21 has been shown to associate with integrin subunits and to be important for receptor entry into cells via RAB5/RAB21 endosomes. The GTPase-activating protein p120RasGAP regulates cell motility by controlling the return of the endocytosed integrins to the plasma membrane by competing with RAB21 for binding to overlapping sites on the α -tail of endocytosed integrin.
NCBI Gene ID
23011
Swiss Prot
Q9UL25
Accession Number
NP_055814
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
RAB21 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1405 - Mouse Kidney Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (95%)
Buffer
RAB21 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RAB21 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
This antibody is predicted to not cross-react with other Ras-related proteins
Symbol
RAB21
Positive Control 2
Cat. No. 10-401 - Human Kidney Tissue Slide
NCBI Official Name
RAB21, member RAS oncogene family
NCBI Organism
Homo sapiens
Background Reference 01
Opdam FJ, Kamps G, Croes H, et al. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. Eur. J. Cell Biol. 2000; 79:308-16.
Background Reference 02
Pellinen T and Ivaska J. Integrin traffic. J. Cell Sci. 2006; 119:3723-31.
Background Reference 04
Mai A, Veltel S, Pellinen T, et al. Competitive binding of Rab21 and p120RasGAP to integrins regulates receptor traffic and migration. J. Cell Biol. 2011; 194:291-306.
Other Product Names
RAB21 Antibody: KIAA0118, Ras-related protein Rab-21
Tested Applications
ELISA, WB, IF
Protein ID
7661922
Physical Properties
Liquid

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