ESRRB Antibody

• Background:

  ESRRB Antibody: The estrogen-related receptor beta (ESRRB) was initially identified in mouse embryonic carcinoma stem cells and was found to be expressed exclusively in trophoblast progenitor cells between days 6.5 and 7.5 post coitum. Recent studies have shown that ESRRB is part of an POU5F1/Oct4-centered protein interaction network in embryonic stem (ES) cells. It is thought to interact with other ES transcription factors such as NANOG within this network, activating POU5F1 transcription and thereby sustaining self-renewal and pluripotency in ES cells.

• NCBI Gene ID:

  2103

• Swiss Prot:

  O95718

• Accession Number:

  NP_004443

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Stem Cell

• Purification:

  ESRRB Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1301 - Human Heart Tissue Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (89%), Rat: (89%)

• Buffer:

  ESRRB Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  ESRRB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  ESRRB

• Positive Control 2:

  Cat. No. 10-501 - Human Heart Tissue Slide

• NCBI Official Name:

  Estrogen-related receptor beta

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Pettersson K, Svensson K, Mattsson R, et al. Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech. Dev. 1996; 54:211-23.

• Background Reference 02:

  Van den Berg DL, Snoek T, Mullin NP, et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 2010; 6:369-81.

• Background Reference 03:

  Zhang X, Zhang J, Wang T, et al. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J. Biol. Chem. 2008; 283:35825-33.

• Other Product Names:

  ESRRB Antibody: ERR2, ERRb, ESRL2, NR3B2, DFNB35, ERRB2, Steroid hormone receptor ERR2, ERR beta-2, ERR-beta

• Tested Applications:

  ELISA, WB, IHC-P, IF

• Protein ID:

  238550159

• Physical Properties:

  Liquid