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ESRRB Antibody

CAT: 0223-6813-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6813-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ESRRB Antibody: The estrogen-related receptor beta (ESRRB) was initially identified in mouse embryonic carcinoma stem cells and was found to be expressed exclusively in trophoblast progenitor cells between days 6.5 and 7.5 post coitum. Recent studies have shown that ESRRB is part of an POU5F1/Oct4-centered protein interaction network in embryonic stem (ES) cells. It is thought to interact with other ES transcription factors such as NANOG within this network, activating POU5F1 transcription and thereby sustaining self-renewal and pluripotency in ES cells.
NCBI Gene ID
2103
Swiss Prot
O95718
Accession Number
NP_004443
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
ESRRB Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1301 - Human Heart Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (89%), Rat: (89%)
Buffer
ESRRB Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
ESRRB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ESRRB
Positive Control 2
Cat. No. 10-501 - Human Heart Tissue Slide
NCBI Official Name
Estrogen-related receptor beta
NCBI Organism
Homo sapiens
Background Reference 01
Pettersson K, Svensson K, Mattsson R, et al. Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech. Dev. 1996; 54:211-23.
Background Reference 02
Van den Berg DL, Snoek T, Mullin NP, et al. An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 2010; 6:369-81.
Background Reference 03
Zhang X, Zhang J, Wang T, et al. Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J. Biol. Chem. 2008; 283:35825-33.
Other Product Names
ESRRB Antibody: ERR2, ERRb, ESRL2, NR3B2, DFNB35, ERRB2, Steroid hormone receptor ERR2, ERR beta-2, ERR-beta
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
238550159
Physical Properties
Liquid

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