TFEB Antibody

• Background:

  The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors (1,2) . Recent studies have shown that lysosomal biogenesis is regulated by TFEB (3), which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1 (4) . Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes (5) .

• NCBI Gene ID:

  7942

• Swiss Prot:

  P19484

• Accession Number:

  NP_009093

• Host:

  Rabbit

• Reactivity:

  Human

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Autophagy

• Purification:

  TFEB antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 10-101 - Human Lung Tissue Slide

• Concentration:

  1 mg/mL

• Buffer:

  TFEB antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  TFEB antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

• Fragment:

  IgG

• Specificity:

  TFEB antibody is human specific. At least three isoforms of TFEB are known to exist.

• Symbol:

  TFEB

• NCBI Official Name:

  Transcription factor EB

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Carr CS and Sharp PA. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins. Mol. Cell Biol. 1990; 10:4384-8.

• Background Reference 02:

  Davis IJ, Hsi BL, Arroyo JD, et al. Cloning of an alpha-TFEB fusion in renal tumors harboring the t (6;11) (p21; q13) chromosome translocation. Proc. Natl. Acad. Sci. USA 2003; 100:6051-6.

• Background Reference 03:

  Sardiello M, Palmieri M, di Ronza A, et al. A gene network regulating lysosomal biogenesis and function. Science 2009; 325:473-7.

• Background Reference 04:

  Pena-Llopis S, Vega-Rubin-de-Celis S, Schwartz JC, et al. Regulation of TFEB and V-ATPases my mTORC1. EMBO J. 2011; 30:3242-58.

• Other Product Names:

  TFEB Antibody: TCFEB, BHLHE35, ALPHATFEB, Transcription factor EB, Class E basic helix-loop-helix protein 35, bHLHe35

• Tested Applications:

  ELISA, IHC-P, IF

• Protein ID:

  24307933

• Physical Properties:

  Liquid